Professor
전영수
Jun, Youngsoo
- LAB NAMECellular Logistics and Aging Research Laboratory세포로지스틱스 및 세포노화 연구실
- E-MAILjunys@gist.ac.kr
- TEL062-715-2510
- WEBSITEhttp://clar.gist.ac.kr/
EDUCATION
- 2007: Doctor of Philosophy, Dartmouth College, Hanover, NH
- (Thesis: Biochemical Characterization of Yeast Vacuole Docking, Hemifusion, and Fusion,
- Thesis advisor: William T. Wickner)
- 2000: Master of Science, Korea University, Seoul, South Korea.
- (Thesis: Effects of Human Cytomegalovirus US proteins on Non-classical MHC Class I
- Molecules-mediated Antigen Presentation, Thesis advisor: Kwangseog Ahn)
- 1997: Bachelor of Science, Korea University, Seoul, South Korea
WORK EXPERIENCE
- 2019-present: Professor, Gwangju Institute of Science and Technology (GIST), School of
- Life Sciences
- 2016-present: Director, Cell Logistics Research Center at GIST (Advanced Research
- Center funded by National Research Foundation of Korea)
- 2018-2019: Visiting Associate Professor Geisel School of Medicine at Dartmouth,
- Department of Biochemistry and Cell Biology GIST
- 2014-2019: Associate Professor, Gwangju Institute of Science and Technology (GIST),
- School of Life Sciences
- 2009-2014: Assistant Professor, Gwangju Institute of Science and Technology (GIST),
- School of Life Sciences
- 2008-2009: Postdoctoral fellow, Laboratory of Dr. Kwangseog Ahn, Seoul National
- University, Department of Biological Sciencies
- 2007-2008: Postdoctoral fellow, Laboratory of Dr. David Bilder, University of California at
- Berkeley, Department of Molecular and Cell Biology
- 2007: Postdoctoral fellow, Laboratory of Dr. William T. Wickner, Dartmouth Medical
- School, Department of Biochemistry.
- 2000-2001: Research Associate, Laboratory of Dr. Kwangseog Ahn, Korea University
- Graduate School of Life Sciences and Biotechnology
HONORS_AWARDS
- Commendation from Minister of Ministry of Science, ICT and Future Planning of Korea, 2016
- The Blue Ribbon Lecture Award, the Korean Society for Molecular and Cellular Biology,
- 2011
- E. Lucile Smith Award for Excellence in Biochemistry, Department of Biochemistry,
- Dartmouth Medical School, 2006
REPRESENTATIVE_PUBLICATIONS
- Youngsoo Jun (2019) An in vitro assay of trans-SNARE complex formation during yeast
- vacuole fusion using epitope tag-free SNAREs. Methods in Molecular Biology, 1860:277-
- 288
- Miriam Lee, Yeojin Moon, Sanghwa Lee, Changwook Lee, and Youngsoo Jun (2019)
- Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane
- fusion in Saccharomyces cerevisiae. FASEB Journal, 33:3590
- Kim HR, Mun Y, Lee KS, Park YJ, Park JS, Park JH, Jeon BN, Kim CH, Youngsoo Jun, Hyun
- YM, Lee SM, Park CS, Im SH, Jun CD (2018) T cell microvilli constitute immunological
- synaptosomes that carry messages to antigen-presenting cells. Nature Communications,
- 9:3630
- Kim HR, Kwon MS, Lee S, Mun Y, Lee KS, Kim CH, Na BR, Kim BNR, Piragyte I, Lee HS,
- Youngsoo Jun, Jin MS, Hyun YM, Jung HS, Mun JY, Jun CD (2018) TAGLN2 polymerizes Gactin
- in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions.
- Scientific Reports, 8:5503
- Hanbin Jeong, Jumi Park, Youngsoo Jun, and Changwook Lee (2017) Crystal structures of
- Mmm1 and Mdm12-Mmm1 reveal mechanistic insight into phospholipid trafficking at ERmitochondria
- contact sites. Proc. Natl. Acad. Sci. USA, 114:E9502-9511
- Kyung Tae Kim, Yeojin Moon, Yunsu Jang, Kang Taek Lee, Changwook Lee, Youngsoo Jun*,
- and Sanghwa Lee* (2017) Molecular mechanisms of atlastin-mediated ER membrane fusion
- revealed by a FRET-based single-vesicle fusion assay. Scientific Reports 7:8700. *Co-corresponding authors
- Hanbin Jeong, Jumi Park, Hye-In Kim, Miriam Lee, Young-Joon Ko, Sanghwa Lee, Youngsoo
- Jun*, and Changwook Lee* (2017) Mechanistic insight into the nucleus-vacuole junction based
- on the Vac8p-Nvj1p crystal structure. Proc. Natl. Acad. Sci. USA, 114:E4539-E4548.*Cocorresponding
- authors
- Vipul Gurjati, Miriam Lee, Young-Joon Ko, Sangeun Lee, Daejin Kim, Hyungjun Kim, Sukmo
- Kang, Soyoung Lee, Jinjoo Kim, Hyungsu Jeon, Sun Chang Kim, Youngsoo Jun*, and
- Sangyong Jon* (2016) Bioengineered yeast-derived vacuoles with enhanced tissuepenetrating
- ability for targeted cancer therapy. Proc. Natl. Acad. Sci. USA, 113:710-715.
- *Co-corresponding authors
- Hanbin Jeong, Hyo Jung Sim, Eun Kyung Song, Hakbong Lee, Sung Chul Ha, Youngsoo
- Jun, Tae Joo Park, and Changwook Lee (2016) Crystal structure of SEL1L:Insight into the
- roles of SLR motifs in ERAD pathway. Scientific Reports 6:20261
- Eun Jo Do, Tae Jung Ahn, Ji Hye Lee, Jeong-Ho Park, Sun Hwa Park, Tong Mook Kang,
- Hana Cho, Tae Jin Kim, Hyung-Wook Kim, Youngsoo Jun, Hee Jae Lee, Young Sik Lee,
- Jae Young Kwon, and KyeongJin Kang (2016) TrpA1 regulates defecation of food-borne
- pathogens under the control of the duox pathway. PLOS genetics 12:e1005773.
- Miriam Lee*, Young-Joon Ko*, Yeojin Moon, Minsoo Han, Hyung-Wook Kim, Sung Haeng
- Lee, KyeongJin Kang, and Youngsoo Jun (2015) SNAREs support atlastin-mediated
- homotypic ER fusion in Saccharomyces cerevisiae. The Journal of Cell Biology. 210:451-
- 470 (Selected as a significant article for “In This Issue”) *Co-first authors
- Young-Joon Ko*, Miriam Lee*, KyeongJin Kang, Woo Keun Song, and Youngsoo Jun
- (2014) In vitro assay using engineered yeast vacuoles for neuronal SNARE-mediated
- membrane fusion. Proc. Natl. Acad. Sci. USA, 111:7677-7682. *Co-first authors
- Sunglim Cho, Bo-Young Kim, Kwangseog Ahn, and Youngsoo Jun (2013) The C-terminal
- amino acid of the MHC-I heavy chain is critical for binding to Derlin-1 in human
- cytomegalovirus US11-induced MHC-I degradation. PLoS One 8:e72356.
- Sunglim Cho, Miriam Lee, and Youngsoo Jun (2013) Forced interaction of cell surface
- proteins with Derlin-1 in the endoplasmic reticulum is sufficient to induce their dislocation into
- the cytosol for degradation. Biochem. Biophys. Res. Commun 430:787-792.
- Hao Xu, Michael Zick, William T. Wickner, and Youngsoo Jun (2011) A lipid-anchored
- SNARE supports membrane fusion. Proc. Natl. Acad. Sci. USA, 108:17325-17330.
- Sunglim Cho and Youngsoo Jun (2011) Human CD1d molecules are resistant to human
- cytomegalovirus US2- and US11-mediated degradation. Biochem. Biophys. Res.
- Commun., 413:616-622.
- Sunglim Cho, Jeongmin Ryoo, Youngsoo Jun*, and Kwangseog Ahn* (2011) Receptormediated
- ER export of human MHC class I molecules is regulated by the C-terminal single
- amino acid. Traffic, 12:42-55 *Co-corresponding authors.
- Hao Xu, Youngsoo Jun, Thompson J, Yates J, and William Wickner (2010) HOPS prevents
- the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion.
- The EMBO Journal, 29:1948-1960
- Joji Mima, Christopher M. Hickey, Hao Xu, Youngsoo Jun, and William Wickner (2008)
- Reconstituted membrane fusion requires regulatory lipids, SNAREs, and synergistic SNARE
- chaperones. The EMBO Journal, 27:2031-2042
- Youngsoo Jun, Hao Xu, and William Wickner. (2007) The addition of Sec18p (NSF) and the
- soluble SNARE Vam7p allows a lipid-anchored R-SNARE to support yeast vacuole fusion.
- The EMBO Journal, 26:4935-4945.
- Vincent Starai*, Youngsoo Jun*, and William Wickner. (2007) Excess Vacuolar SNAREs
- Drive Lysis and Rab-bypass Fusion. Proc. Natl. Acad. Sci. USA, 104:13551-13558. *Cofirst
- authors. (Feature Article, Direct Submission) - Rated “Exceptional” by the Faculty of
- 1000
- Youngsoo Jun and William Wickner. (2007) New Assays of Vacuole Fusion Resolve the
- Stages of Docking, Lipid Mixing, and Content Mixing. Proc. Natl. Acad. Sci. USA,
- 104:13010-13015. (Direct Submission)
- Youngsoo Jun, Naomi Thorngren, Vincent Starai, Rutilio A. Fratti, Kevin Collins, and William
- Wickner. (2006) Reversible, Cooperative Reactions of Yeast Vacuole Docking. The EMBO
- Journal, 25:5260-5269.
- Youngsoo Jun, Rutilio A. Fratti, and William Wickner. (2004) Diacylglycerol and its
- Formation by Phospholipase C Regulate Rab- and SNARE-dependent Yeast Vacuole
- Fusion. The Journal of Biological Chemistry, 279:53186-53195.
- Rutilio A. Fratti, Youngsoo Jun, Alexy J. Merz, Nathan Margolis, and William Wickner.
- (2004) Interdependent Assembly of Specific Regulatory Lipids and Membrane Fusion
- Proteins into the Vertex Ring Domain of Docked Vacuoles. Journal of Cell Biology,
- 167:1087-1098.
- Youngsoo Jun, Eunok Kim, Mirim Jin, Ha Chin Sung, Hoon Han, Daniel E. Geraghty, and
- Kwangseog Ahn. (2000) Human Cytomegalovirus Gene Products US3 and US6 DownRegulate
- Trophoblast Class I MHC Molecules. The Journal of Immunology, 164:805-811.
